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Amitriptyline and Chlordiazepoxide


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    Related terms

      • It is used to treat low mood (depression).
      • It is used to treat anxiety.
      • Amitriptyline raises chemicals in the brain.
      • Chlordiazepoxide calms the brain.
      • With low mood (depression), sleep and eating habits may get better fast. Other signs may take up to 4 to 6 weeks to get better.


      How to take

      • Take with or without food. Take with food if it causes an upset stomach.

      Missed Dose

      • Take a missed dose as soon as you think about it.
      • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
      • Do not take 2 doses at the same time or extra doses.
      • Do not change the dose or stop this drug. Talk with the doctor.


      • Store at room temperature.
      • Protect from light.
      • Protect from water. Do not store in a bathroom or kitchen.



      • The want to harm yourself is an unsafe sign of low mood (depression). It may last until your low mood is fully treated. If you are planning on harming yourself, call the ER (emergency department) right away.
      • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.
      • Please read the medication guide.


      • If you have an allergy to amitriptyline, chlordiazepoxide, or any other part of this drug.
      • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
      • If you have any of these health problems: Glaucoma or recent heart attack.
      • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this drug is started. Taking both at the same time could cause risky high blood pressure.
      • If you are pregnant or may be pregnant.
      • If you are breast-feeding.


      • This drug may be habit-forming with long-term use.
      • If you have been taking this drug for many weeks, talk with your doctor before stopping. You may want to slowly stop this drug.
      • If you have kidney disease, talk with your doctor.
      • If you have liver disease, talk with your doctor.
      • If you have lung disease, talk with your doctor. You may be more sensitive to this drug.
      • If you have seizures, talk with your doctor.
      • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
      • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
      • Avoid beer, wine, mixed drinks, or other drugs and natural products that slow your actions.
      • Avoid grapefruit and grapefruit juice.
      • You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
      • You may have more chance of cavities.
      • Use birth control that you can trust to stop pregnancy while taking this drug.

      Side Effects

      • Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
      • Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing.
      • Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.
      • Dry mouth. Good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. See a dentist often.

      Contact a healthcare provider

      • If you think there was an overdose, call your local poison control center or ER right away.
      • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
      • If you are planning to harm yourself or the want to harm yourself gets worse.
      • Very bad dizziness or passing out.
      • Change in thinking clearly and with logic.
      • Big change in balance.
      • Not able to pass urine.
      • Feeling very tired or weak.
      • Any rash.
      • Side effect or health problem is not better or you are feeling worse.

      General Statements

      • If you have a very bad allergy, wear an allergy ID at all times.
      • Do not share your drugs with others and do not take anyone else's drugs.
      • Keep all drugs out of the reach of children and pets.
      • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
      • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
      • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
      • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
      • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

      Author information
      • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

      Copyright © 2011 Natural Standard (

      The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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