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Hyaluronate and Derivatives


Related terms
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    Related terms
    • Brand Names: U.S.: Amvisc®;Amvisc® Plus;Bionect®;Euflexxa®;Hyalgan®;Hylase® Wound;Juvéderm® Ultra;Juvéderm® Ultra Plus;Juvéderm® Ultra Plus XC;Juvéderm® Ultra XC;Orthovisc®;Perlane®;Provisc®;Restylane®;Supartz®;Synvisc-One®;Synvisc®
    • Brand Names: Canada: Cystistat®;Durolane®;OrthoVisc®;Suplasyn®

    • Eye:
    • It is used for eye surgeries.
    • Knee:
    • It is used to treat arthritis.
    • Lips:
    • It is used to make the lips bigger.
    • Skin shot:
    • It is used to lower the number of lines and wrinkles of the face and neck.
    • Topical:
    • It is used to promote healing of skin ulcers and wounds.
    • Eye:
    • It helps give a better surface for eye surgery.
    • Knee:
    • It loosens the joint area around the knee.
    • Lips:
    • It adds volume to the lips.
    • Skin shot:
    • It adds volume and thickness to skin making wrinkles and folds less.
    • Topical:
    • It helps the skin keep water which helps with wound healing.


    How to take

    • Eye:
    • It is given as a shot into the eye.
    • Knee:
    • It is given as a shot into the knee.
    • Lips:
    • It is given as a shot into the lips.
    • Skin shot:
    • It is given as a shot into the skin of the face.
    • Topical:
    • Do not take this drug by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
    • Wash your hands before and after use.
    • Clean affected part before use. Make sure to dry well.
    • Put a thin layer on the affected skin.
    • Cover the wound with a clean dressing.

    Missed Dose

    • Call your doctor for an office visit.
    • Skin topical:
    • Put on a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not put on 2 doses or extra doses.


    • Skin gel:
    • Store at room temperature.
    • Eye, knee, lip, skin (shot):
    • This drug will be given to you in a hospital or doctor's office. You will not store it at home.



    • If you have an allergy to hyaluronic acid or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have an allergy to birds or eggs, talk with your doctor.
    • If you have a latex allergy, talk with your doctor.
    • Knee:
    • If you have an infected joint.
    • Lips:
    • If you are younger than 21 years of age.
    • If you have bleeding problems.
    • Skin:
    • If you are younger than 18 years of age.
    • If you have a skin infection.
    • If you have bleeding problems.
    • If you have an allergy to lidocaine, talk with your doctor.


    • All products:
    • Talk with your doctor before using products that have aspirin, blood thinners, garlic, ginseng, ginkgo, ibuprofen or like products, pain drugs, or vitamin E.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.
    • Knee:
    • Avoid activity for 48 hours or as you have been told by your doctor.
    • Skin shot:
    • Avoid sun, sunlamps, and tanning beds until the swelling is gone.
    • Avoid cold weather until swelling is gone.

    Side Effects

    • Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
    • Headache.
    • Bruising.
    • Swelling.
    • Eye:
    • Eye irritation.
    • More eye pressure.
    • Knee, lip, skin shot:
    • Irritation where the shot is given.
    • Topical:
    • Skin irritation.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Trouble breathing.
    • Very bad swelling.
    • Very bad belly pain.
    • Chest pain or pressure, a fast heartbeat, or passing out.
    • Very bad skin irritation.
    • Sudden change in eyesight, eye pain, or irritation.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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