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Related terms
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    Related terms
    • Brand Names: U.S.: AprisoT;Asacol®;Asacol® HD;Canasa®;Lialda®;Pentasa®;Rowasa®;sfRowasaT
    • Brand Names: Canada: 5-ASA;Asacol®;Asacol® 800;Mesasal®;Mezavant®;Novo-5 ASA;Novo-5 ASA-ECT;Pentasa®;Salofalk®;Salofalk® 5-ASA

    • It is used to treat mild to moderate disease at the far end of the colon.
    • It is used to treat ulcerative colitis.
    • Mesalamine lowers irritation and swelling.


    How to take

    • Use as you have been told, even if you are feeling better.
    • Mezavant® and Lialda®: Take with a meal.
    • Take with a full glass of water.
    • Swallow tablet or capsule whole. Do not chew, break, or crush.
    • Use suppository or suspension rectally.
    • Shake suspension well before use.
    • Keep suspension in your rectum as long as you can.
    • Take foil off the rectal suppository and put in, pointed end first. Do not handle too much. Keep in your rectum for at least 3 hours.
    • You could be on both a tablet or capsule and a rectal product at the same time.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.


    • Oral:
    • Store at room temperature.
    • Protect from water. Do not store in a bathroom or kitchen.
    • Rectal:
    • Store rectal suspension in foil until ready to use. Do not refrigerate.
    • Protect rectal suspension from heat.
    • Protect rectal suspension from light.
    • Do not use if suspension changes color.



    • If you have an allergy to mesalamine, salicylates, sulfasalazine, or any other part of this drug.
    • If you have a sulfite allergy, talk with your doctor.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.


    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • If you have PKU, talk with your doctor. Some products have phenylalanine.
    • If you have kidney disease, talk with your doctor.
    • If you have an inflamed pancreas, talk with your doctor.
    • If you have an inflamed sac around the heart, talk with your doctor.
    • If you have liver disease, talk with your doctor.
    • If you have ulcer disease, talk with your doctor.
    • Have your blood work checked. Talk with your doctor.
    • If you are taking a blood thinner, have your blood work checked. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Do not take AprisoT with antacids.
    • The rectal drug may stain fabric, flooring, painted surfaces, marble, granite, vinyl, and enamel.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Belly pain.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.
    • Headache.
    • Sore throat.
    • Harm to the liver may rarely happen.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Very bad belly pain or bloody loose stools.
    • Trouble breathing.
    • Chest pain or pressure.
    • If you see tablet bits in the stool.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

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    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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